Immuno Concepts was founded in 1979 with a commitment to advance the quality of diagnostic assays for systemic rheumatic diseases.

In 1979 Immuno Concepts pioneered the conversion from rodent tissue to HEp-2 cells for detection of anti-nuclear antibodies (ANAs). Using genetic engineering we developed HEp-2000, an ANA substrate with increased sensitivity for detection of autoantibodies to SS-A/Ro. Immuno Concepts was the first company to offer a non-fluorescent ANA. The company's Colorzyme methodology uses a patented stabilized color reagent system that allows slide-based assays to be read using common bright field microscopy. The Colorzyme format is available for ANA, nDNA and EBV assays.